Programme

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SUNDAY August 31, 2008

  • 15:00 Registration at Rica Ishavs Hotel
  • 19:30 Welcoming remarks: City Hall of Tromso
  • 19:45 Welcome reception in the City Hall of Tromso

MONDAY September 1, 2008

  • 08:30 Opening by Bård Smedsrød
  • 08:45 Key note address by Eddie Wisse:
    Differences in sinusoids and sinusoidal cells in rat, mouse, rabbit, pig and human liver

Session I: Liver sinusoidal endothelial cells: Endocytosis. Chair Eddie Wisse and Bård Smedsrød

  • 09:30 Liver sinusoidal endothelial cells - mega-endocytes (tutorial)
    Peter McCourt
  • 10:00 Molecular biology of hepatic sinusoidal endothelium (tutorial)
    Sergij Goerdt
  • 10:30 Coffee break

Session II Liver sinusoidal endothelial cells: Endocytosis and comparative biology. Chair Masaya Oda and Clark Anderson

  • 11:00 FcγRIIb2 expression in endothelium of liver and placenta (tutorial).
    Clark Anderson
  • 11:30 Endocytosis and recycling of immune complexes mediated by the FcγRIIb2 in rat liver sinusoidal endothelial cells.
    Trond Berg
  • 11:50 Invertebrate analogues of hepatic sinusoidal scavenger systems (tutorial).
    Clive Crossley
  • 12:20 Uptake of oligonucleotides by scavenger endothelial cells in the Atlantic cod (Gadus morhua, L.)
    Montserrat Martin-Armas
  • 12:40 Hypoxia-inducible factor (HIF-1α) and related miRNAs in the regulation of ethanol induced inflammatorygenes in liver sinusoidal endothelial cells (LSECs).
    Vijay K. Kalra
  • 13:00 The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells.
    Inigo Martinez
  • 13:15 Age-related changes in scavenger-receptor mediated endocytosis in rat liver sinusoidal endothelial cells.
    Jaione Simon-Santamaria
  • 13:30 Lunch at Rica Ishavs Hotel & Poster viewing

Session III Liver sinusoidal endothelial cells: Cytoskeleton.
Chair Robert McCuskey and David LeCouteur

  • 14:30 Old age and the hepatic sinusoid (tutorial)
    David LeCouteur
  • 15:00 Age-related dysfunction in the hepatic microcirculation
    Robert McCuskey
  • 15:20 Atherosclerosis, lipoproteins and the liver sieve
    Robin Fraser
  • 15:40 Different expressions of Aquapoint-1 in normal and cirrhotic human liver – Demonstrating the capillarization of hepatic sinusoids
    Masaya Oda
  • 16:00 Coffee break

Session IV Liver sinusoidal endothelial cells: Cytoskeleton cont

  • 16:30 Implication of cortactin, a regulator of actin cytoskeleton assembly, in the control of fenestration in liver sinusoidal endothelial cells
    Frederic Saltel
  • 16:50 Involvement of signaling of VEGF and TGF-b in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells
    Katsuhiko Enomoto
  • 17:10 Integrin LFA-1 enables colon carcinoma cells to upregulate sinusoidal endothelial cell mannose receptor via interleukin-1 dependent mechanism: implications on anti-tumor immunity inhibition during hepatic metastasis
    Beatriz Arteta
  • Social event (to be decided)

TUESDAY September 2, 2008

Session V Kupffer cells
Chair Hartmut Jaeschke and Laura Nagy

  • 09:00 Innate immune responses and alcoholic liver disease: Role of Kupffer cells (tutorial)
    Laura Nagy
  • 09:30 Kinetics and replacement of Kupffer cells after bone marrow transplantation in mice and rats
    Takashi Yamamoto
  • 09:50 High fat feeding induces hepatic insulin resistance and preferential distribution of Kupffer cells around lipid loaded hepatocytes
    Nicolas Lanthier
  • 10:10 Arachidonate 5-lipoxygenase modulates hepatocyte fatty acid uptake and microsomal triglyceride transfer protein activity
    Joan Clária
  • 10:30 Coffee break
  • 11:00 Cross talk between PGE2- and IL-6-mediated signalling pathways in cultured rat Kupffer cells
    Daniela Gärtner
  • 11:20 The inflammatory response during drug-induced liver injury: Toxicity versus regeneration
    Hartmut Jaeschke
  • 11:40 Cecal ligation and puncture sepsis is associated with a shift in adenylyl cyclase expression in sinusoidal liver cells
    Maria K. Dahle
  • 12:00 – 13:00 Business meeting
  • 13:00 – 14:00 Lunch at Rica Ishavs Hotel
  • Excursion: Bus/boat to Sommaroya, and dinner there

WEDNESDAY September 3, 2008

Session VI Stellate cells: signalling and gene regulation
Chair Kenjiro Wake and Jelena Mann

  • 09:00 Splanchnic vitamin A-storing cell system and organ fibrogenesis (tutorial)
    Norifumi Kawada
  • 09:30 Modulation of human hepatic stellate cells chemotaxis by intracellular ROS generation and c-Jun N-terminal kinase activation
    Erica Novo
  • 09:50 Cysteine cathepsins in hepatic stellate cells
    Gunter Maubach
  • 10:10 Canonical Wnt signaling and hepatic stellate cells
    Hidekazu Tsukamoto
  • 10:30 Proliferation of hepatic stellate cells in rats with acute hepatitis is independent on vagal innervation via muscarinic acetylcholine receptor subtype 2
    Ilse Bockx
  • 10:50 Coffee break


Session VII Stellate cells: signaling and gene regulation contd
Chair Haruki Senoo and Hidekazu Tsukamoto

  • 11:20 Epigenetic regulation of hepatic stellate cells (tutorial)
    Jelena Mann
  • 11:50 Rat hepatic stellate cells acquire retinoid responsiveness after activation in vitro
    Yoshihiro Mezak
  • 12:10 Involvement of ADRP and TIP47 in lipid droplets formation of hepatic stellate cells
    Kiwamu Yoshikawa
  • 12:30 Hepatic stellate cells express Tim-2: A possible mediator of ferritin-induced NfκB activation and proinflammatory gene expression
    Richard George Ruddell
  • 12:50 Cellular distribution of lecithin: retinol acyltransferase (LRAT) and cellular retinol binding protein-1 (CRBP-1) in human normal and pathological livers
    Keisuke Nagatsuma
  • 13:10 Salvianolic-acid B inhibits Smads and MAPK signaling induced by transforming growth factor-α1 in activated human hepatic stellate cell line (LX-2)
    Lieming Xu
  • 13:30 – 14:30 Lunch at Rica Ishavs Hotel
  • 14:30 – 15:30 Poster session

Session VIII Stellate cells: modulators of liver fibrosis
Chair Trond Berg and Kenichi Ikejima

  • 15:30 Expression of the transcription factor, early growth response (Egr)-1, is a critical regulator of carbon tetrachloride-induced fibrosis in mice
    Michele Pritchard
  • 15:50 Vitamin E suppressed the proliferation and induced apoptosis of ”activated” hepatic stellate cells
    Noriko Yamaguchi
  • 16:10 Blood platelets in cholestatic liver disease
    Peter Witters
  • 16:30 Study on a rabbit model of steatohepatitis that develops liver cirrhosis
    Tomohiro Ogawa
  • 16:50 C-reactive protein minimizes experimental hepatic fibrosis by inhibiting transactivation of hepatic stellate cells
    Kenichi Ikejima
  • 17:10 Detection and prevention of hepatic fibrosis targeting TGFβ activation
    Soichi Kojima
  • 20:00 Conference dinner at Rica Ishavs Hotel

THURSDAY September 4, 2008

Session IX Stellate cells: comparative morphology and methods
Chair Norifumi Kawada and Soichi Kojima

  • 09:00 Extracellular matrix in sinusoidal wall of frozen mammoths
    Haruki Senoo
  • 09:20 A study of morphological changes in lamprey liver during the course of metamorphosis with special reference to hepatic stellate cells
    Mitsutaka Miura
  • 09:40 Cryopreservation for long-tem storage of human primary cultured hepatic stellate cells
    Anna Nakamura
  • 10:00 Coffee break

Session X Immunology/Tumor
Chair Makoto Naito and Fernando Vidal-Vanaclocha

  • 10:30 Immunobiology of liver sinusoidal endothelial cells (tutorial)
    Percy Knolle
  • 11:00 The prometastatic environment of the liver (tutorial)
    Fernando Vidal-Vanaclocha
  • 11:30 Contribution of tumor-activated sinusoidal endothelium to stellate cell migration into avascular premetastatic niches of colorectal cancer cells in the liver
    Aritz Lopategi
  • 11:50 Tumor-associated macrophages in experimental murine tumors
    Tatyana Korolenko
  • 12.10 Closing remarks by Bård Smedsrød

The following invited speakers will contribute:

  • Special Key Note Lecture: Eddie Wisse: “Differences in sinusoids and sinusoidal cells in rat, mouse, rabbit, pig and human liver”

Tutorial Lectures

  • Peter McCourt: “Liver sinusoidal endothelial cells - mega-endocytes”
  • Sergij Goerdt: “Molecular biology of hepatic sinusoidal endothelium”
  • Clark Anderson: “FcyRIIb2 expression in endothelium of liver and placenta”
  • Clive Crossley: “Invertebrate analogues of hepatic sinusoidal scavenger systems”
  • David LeCouteur: “Old age and the hepatic sinusoid”
  • Laura Nagy: “Innate immune responses and alcoholic liver disease: Role of Kupffer cells”
  • Norifumi Kawada: “Splanchnic vitamin A-storing cell system and organ fibrogenesis”
  • Jelena Mann: “Epigenetic regulation of hepatic stellate cells”
  • Percy Knolle: ”New aspects of LSEC immunobiology”
  • Fernando Vidal-Vanaclocha: “The prometastatic environment of the liver”

Scientific sessions

  • Session I: Liver sinusoidal endothelial cells: Endocytosis
  • Session II: Liver sinusoidal endothelial cells: Endocytosis and comparative biology
  • Sessions III and IV: Liver sinusoidal endothelial cells: Cytoskeleton
  • Session V: Kupffer cells
  • Sessions VI and VII: Stellate cells: signalling and gene regulation
  • Session VIII: Stellate cells: modulators of liver fibrosis
  • Session IX: Stellate cells: comparative morphology and methods
  • Session X: Immunology/Tumor

Main sponsors: Univeristy of Tromsø   Research Council of Norway